Macronutrient balance and lifespan

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Macronutrient balance and lifespan

Dietary restriction (DR) without malnutrition is widely regarded to be a universal mechanism for prolonging lifespan. It is generally believed that the benefits of DR arise from eating fewer calories (termed caloric restriction, CR). Here we argue that, rather than calories, the key determinant of the relationship between diet and longevity is the balance of protein to non-protein energy ingest...

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Macronutrient balance, reproductive function, and lifespan in aging mice.

In invertebrates, reproductive output and lifespan are profoundly impacted by dietary macronutrient balance, with these traits achieving their maxima on different diet compositions, giving the appearance of a resource-based tradeoff between reproduction and longevity. For the first time in a mammal, to our knowledge, we evaluate the effects of dietary protein (P), carbohydrate (C), fat (F), and...

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Optimal macronutrient balance.

There is at present a justifiable debate as to the optimum level of total dietary fat which will reduce the risk of obesity without an elevation of plasma triacylglycerol or a depression of plasma HDL-cholesterol. Total plasma cholesterol and LDL-cholesterol levels are lowered and risk of fatal myocardial infarction is lowered when either saturated or trans-unsaturated fatty acids are replaced ...

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Physiological Regulation of Macronutrient Balance

For centuries the concept of energy balance has provided the bedrock for research into the mechanisms controlling body weight. However, in recent years there has been growing interest in the regulation of the individual macronutrients that combine to determine the energy status of an individual. Thus the classical energy balance equation can be more accurately represented as the integrated sum ...

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Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance

BACKGROUND This study was conducted to evaluate the effects of rhizome powder from the herb Rhodiola rosea, a traditional Western Ukraine medicinal adaptogen, on lifespan and age-related physiological functions of the fruit fly Drosophila melanogaster. RESULTS Flies fed food supplemented with 5.0 mg/ml and 10.0 mg/ml of R. rosea rhizome powder had a 14% to 17% higher median lifespan, whereas ...

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ژورنال

عنوان ژورنال: Aging

سال: 2009

ISSN: 1945-4589

DOI: 10.18632/aging.100098